Here is a list of select publications:
Peer-reviewed Articles
Liggins M, Ramírez Ramírez N, Abel-Santos E. Comparison of sporulation and
germination conditions for Clostridium perfringens type A and G strains.
Front Microbiol. 2023 May 9;14:1143399. doi: 10.3389/fmicb.2023.1143399. PMID:
37228374; PMCID: PMC10203408.
Yip C, Phan JR, Abel-Santos E. Mechanism of germination inhibition of
Clostridioides difficile spores by an aniline substituted cholate derivative
(CaPA). J Antibiot (Tokyo). 2023 Jun;76(6):335-345. doi:
10.1038/s41429-023-00612-3. Epub 2023 Apr 4. PMID: 37016015.
Bhute SS, Mefferd CC, Phan JR, Ahmed M, Fox-King AE, Alarcia S, Villarama JV,
Abel-Santos E, Hedlund BP. A High-Carbohydrate Diet Prolongs Dysbiosis and
Clostridioides difficile Carriage and Increases Delayed Mortality in a Hamster
Model of Infection. Microbiol Spectr. 2022 Aug 31;10(4):e0180421. doi:
10.1128/spectrum.01804-21. Epub 2022 Jun 16. PMID: 35708337; PMCID: PMC9431659.
Sharma SK, Yip C, Simon MP, Phan J, Abel-Santos E, Firestine SM. Studies on
the Importance of the 7α-, and 12α- hydroxyl groups of
N-Aryl-3α,7α,12α-trihydroxy-5β-cholan-24-amides on their Antigermination
Activity Against a Hypervirulent Strain of Clostridioides (Clostridium)
difficile. Bioorg Med Chem. 2021 Dec 15;52:116503. doi:
10.1016/j.bmc.2021.116503. Epub 2021 Nov 10. PMID: 34837818; PMCID: PMC9236192.
Phan JR, Do DM, Truong MC, Ngo C, Phan JH, Sharma SK, Schilke A, Mefferd CC,
Villarama JV, Lai D, Consul A, Hedlund BP, Firestine SM, Abel-Santos E. An
Aniline-Substituted Bile Salt Analog Protects both Mice and Hamsters from
Multiple Clostridioides difficile Strains. Antimicrob Agents Chemother. 2022 Jan
18;66(1):e0143521. doi: 10.1128/AAC.01435-21. Epub 2021 Nov 15. PMID: 34780262;
PMCID: PMC8765400.
Yip C, Okada NC, Howerton A, Amei A, Abel-Santos E. Pharmacokinetics of
CamSA, a potential prophylactic compound against Clostridioides difficile
infections. Biochem Pharmacol. 2021 Jan;183:114314. doi:
10.1016/j.bcp.2020.114314. Epub 2020 Nov 3. PMID: 33152344; PMCID: PMC7770080.
Mefferd CC, Bhute SS, Phan JR, Villarama JV, Do DM, Alarcia S, Abel-Santos E,
Hedlund BP. A High-Fat/High-Protein, Atkins-Type Diet Exacerbates
Clostridioides (Clostridium) difficile Infection in Mice,
whereas a High-Carbohydrate Diet Protects. mSystems. 2020 Feb 11;5(1):e00765-19.
doi: 10.1128/mSystems.00765-19. PMID: 32047064; PMCID: PMC7018531.
Howerton A, Seymour CO, Murugapiran SK, Liao Z, Phan JR, Estrada A, Wagner
AJ, Mefferd CC, Hedlund BP, Abel-Santos E. Effect of the Synthetic Bile Salt
Analog CamSA on the Hamster Model of Clostridium difficile Infection. Antimicrob
Agents Chemother. 2018 Sep 24;62(10):e02251-17. doi: 10.1128/AAC.02251-17. PMID:
30012758; PMCID: PMC6153836.
Sharma SK, Yip C, Esposito EX, Sharma PV, Simon MP, Abel-Santos E, Firestine
SM. The Design, Synthesis, and Characterizations of Spore Germination Inhibitors
Effective against an Epidemic Strain of Clostridium difficile. J Med Chem. 2018
Aug 9;61(15):6759-6778. doi: 10.1021/acs.jmedchem.8b00632. Epub 2018 Jul 30.
PMID: 30004695; PMCID: PMC6192251.
Alvarado I, Margotta JW, Aoki MM, Flores F, Agudelo F, Michel G, Elekonich
MM, Abel-Santos E. Inhibitory effect of indole analogs against Paenibacillus
larvae, the causal agent of American foulbrood disease. J Insect Sci. 2017 Sep
1;17(5):104. doi: 10.1093/jisesa/iex080. PMID: 29117379; PMCID: PMC7206643.
Alvarado I, Elekonich MM, Abel-Santos E, Wing HJ. Comparison of in vitro
methods for the production of Paenibacillus larvae endospores. J Microbiol
Methods. 2015 Sep;116:30-2. doi: 10.1016/j.mimet.2015.06.011. Epub 2015 Jun 27.
PMID: 26130193.
Alvarado I, Abel-Santos E. How enteric pathogens know they hit the sweet
spot. Future Microbiol. 2014;9(1):13-6. doi: 10.2217/fmb.13.141. PMID: 24328376;
PMCID: PMC9536218.
Howerton A, Patra M, Abel-Santos E. Fate of ingested Clostridium difficile
spores in mice. PLoS One. 2013 Aug 30;8(8):e72620. doi:
10.1371/journal.pone.0072620. PMID: 24023628; PMCID: PMC3758320.
Howerton A, Patra M, Abel-Santos E. A new strategy for the prevention of
Clostridium difficile infection. J Infect Dis. 2013 May 15;207(10):1498-504.
doi: 10.1093/infdis/jit068. Epub 2013 Feb 18. PMID: 23420906.
Alvarado I, Phui A, Elekonich MM, Abel-Santos E. Requirements for in vitro
germination of Paenibacillus larvae spores. J Bacteriol. 2013
Mar;195(5):1005-11. doi: 10.1128/JB.01958-12. Epub 2012 Dec 21. PMID: 23264573;
PMCID: PMC3571325.
Luu H, Akoachere M, Patra M, Abel-Santos E. Cooperativity and interference
of germination pathways in Bacillus anthracis spores. J Bacteriol. 2011
Aug;193(16):4192-8. doi: 10.1128/JB.05126-11. Epub 2011 Jun 17. PMID: 21685276;
PMCID: PMC3147676.
Liggins M, Ramirez N, Magnuson N, Abel-Santos E. Progesterone analogs
influence germination of Clostridium sordellii and Clostridium difficile spores
in vitro. J Bacteriol. 2011 Jun;193(11):2776-83. doi: 10.1128/JB.00058-11. Epub
2011 Apr 8. PMID: 21478359; PMCID: PMC3133115.
Howerton A, Ramirez N, Abel-Santos E. Mapping interactions between
germinants and Clostridium difficile spores. J Bacteriol. 2011
Jan;193(1):274-82. doi: 10.1128/JB.00980-10. Epub 2010 Oct 22. PMID: 20971909;
PMCID: PMC3019946.
Alvarez Z, Lee K, Abel-Santos E. Testing nucleoside analogues as inhibitors
of Bacillus anthracis spore germination in vitro and in macrophage cell culture.
Antimicrob Agents Chemother. 2010 Dec;54(12):5329-36. doi: 10.1128/AAC.01029-10.
Epub 2010 Oct 4. PMID: 20921305; PMCID: PMC2981234.
Ross CA, Abel-Santos E. Guidelines for nomenclature assignment of Ger
receptors. Res Microbiol. 2010 Dec;161(10):830-7. doi:
10.1016/j.resmic.2010.08.002. Epub 2010 Sep 24. PMID: 20870021; PMCID:
PMC3005893.
Ramirez N, Liggins M, Abel-Santos E. Kinetic evidence for the presence of
putative germination receptors in Clostridium difficile spores. J Bacteriol.
2010 Aug;192(16):4215-22. doi: 10.1128/JB.00488-10. Epub 2010 Jun 18. PMID:
20562307; PMCID: PMC2916422.
Ross C, Abel-Santos E. The Ger receptor family from sporulating bacteria.
Curr Issues Mol Biol. 2010;12(3):147-58. PMID: 20472940; PMCID: PMC3081667.
Dodatko T, Akoachere M, Jimenez N, Alvarez Z, Abel-Santos E. Dissecting
interactions between nucleosides and germination receptors in Bacillus cereus
569 spores. Microbiology (Reading). 2010 Apr;156(Pt 4):1244-1255. doi:
10.1099/mic.0.030270-0. Epub 2009 Dec 24. PMID: 20035009; PMCID: PMC2889443.
Ramirez N, Abel-Santos E. Requirements for germination of Clostridium
sordellii spores in vitro. J Bacteriol. 2010 Jan;192(2):418-25. doi:
10.1128/JB.01226-09. Epub 2009 Nov 13. PMID: 19915025; PMCID: PMC2805323.
Dodatko T, Akoachere M, Muehlbauer SM, Helfrich F, Howerton A, Ross C,
Wysocki V, Brojatsch J, Abel-Santos E. Bacillus cereus spores release alanine
that synergizes with inosine to promote germination. PLoS One. 2009 Jul
28;4(7):e6398. doi: 10.1371/journal.pone.0006398. PMID: 19636427; PMCID:
PMC2712684.
Alvarez Z, Abel-Santos E. Potential use of inhibitors of bacteria spore
germination in the prophylactic treatment of anthrax and Clostridium difficile–
associated disease. Expert Rev Anti Infect Ther. 2007 Oct;5(5):783-92. doi:
10.1586/14787210.5.5.783. PMID: 17914913.
Akoachere M, Squires RC, Nour AM, Angelov L, Brojatsch J, Abel-Santos E.
Identification of an in vivo inhibitor of Bacillus anthracis spore germination.
J Biol Chem. 2007 Apr 20;282(16):12112-8. doi: 10.1074/jbc.M611432200. Epub 2007
Feb 12. PMID: 17296608.
Nilsson LO, Louassini M, Abel-Santos E. Using siclopps for the discovery of
novel antimicrobial peptides and their targets. Protein Pept Lett. 2005
Nov;12(8):795-9. doi: 10.2174/0929866054864247. PMID: 16305551; PMCID:
PMC6192245.
Abel-Santos E, Scott CP, Benkovic SJ. Use of inteins for the in vivo
production of stable cyclic peptide libraries in E. coli. Methods Mol Biol.
2003;205:281-94. doi: 10.1385/1-59259-301-1:281. PMID: 12491894.
Scott CP, Abel-Santos E, Jones AD, Benkovic SJ. Structural requirements for
the biosynthesis of backbone cyclic peptide libraries. Chem Biol. 2001
Aug;8(8):801-15. doi: 10.1016/s1074-5521(01)00052-7. PMID: 11514229.
Trakselis MA, Alley SC, Abel-Santos E, Benkovic SJ. Creating a dynamic
picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by
using fluorescence resonance energy transfer. Proc Natl Acad Sci U S A. 2001 Jul
17;98(15):8368-75. doi: 10.1073/pnas.111006698. PMID: 11459977; PMCID: PMC37445.
Alley SC, Abel-Santos E, Benkovic SJ. Tracking sliding clamp opening and
closing during bacteriophage T4 DNA polymerase holoenzyme assembly.
Biochemistry. 2000 Mar 21;39(11):3076-90. doi: 10.1021/bi992377r. PMID:
10715129.
Scott CP, Abel-Santos E, Wall M, Wahnon DC, Benkovic SJ. Production of
cyclic peptides and proteins in vivo. Proc Natl Acad Sci U S A. 1999 Nov
23;96(24):13638-43. doi: 10.1073/pnas.96.24.13638. PMID: 10570125; PMCID:
PMC24117.
Alley SC, Shier VK, Abel-Santos E, Sexton DJ, Soumillion P, Benkovic SJ.
Sliding clamp of the bacteriophage T4 polymerase has open and closed subunit
interfaces in solution. Biochemistry. 1999 Jun 15;38(24):7696-709. doi:
10.1021/bi9827971. PMID: 10387009.
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